On occasion, ThreatDown (aka Malwarebytes) can consume too much space on Mac computers, resulting in sudden and unexpected warnings that the hard drive has run out of space even though the hard drive previously had plenty of storage space available.
sudo launchctl stop com.malwarebytes.agent.daemon
cd /Library/Application\ Support/Malwarebytes/Malwarebytes\ Endpoint\ Agent/Data/EDRWork/
sudo rm -f FRCoreDB
sudo launchctl start com.malwarebytes.agent.daemon